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Evolutionary Conserved N-Terminal Domain of Nrf2 Is Essential for the Keap1-Mediated Degradation of the Protein by Proteasome

During ligation-period, nitric oxide- and malondialdehyde-level in liver remained within normal healthy values, and increased serum enzymes markedly lessened

doi:10.1111/j.1365-3164.2007.00647.x

Preclinical research suggests it remains effective even at very low doses, with no significant toxicity observed in animal studies