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Contraindications include: pregnancy and lactation, personal or family history of medullary thyroid carcinoma, Multiple Endocrine Neoplasia syndrome type 2 (MEN-2), history of pancreatitis, type 1 diabetes, severe gastrointestinal disease (including gastroparesis), and known hypersensitivity to GLP-1 analogues

INTRODUCTION The physiological role of the gastrointestinal tract was traditionally thought to involve nutrient digestion and absorption, but it is now known to be the source of a plethora of peptide hormones involved in the regulation of metabolism and other body functions (Baggio & Drucker, 2007)

The insulin concentration in the low- and high-glucose groups was measured using a Rat/Mouse Insulin ELISA kit (Merck KGaA, Darmstadt, Germany)

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Side Effects Like all medications, semaglutide can have side effects

And has been involved in every area from research to clinical practice, to advocacy to leadership