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We have demonstrated the beneficial effect of G49, a dualAG, in resolving metabolic-dysfunction associated steatohepatitis (MASH) and improving liver regeneration under this pathological condition in C57BL/6J mice by targeting multiple homeostatic mechanisms including inflammation, oxidative/endoplasmic reticulum stress, mitochondrial dysfunction, and shifting glucose metabolism 13

Likewise, sex differences in the way some of these drugs are absorbed and metabolized has been noted 37 , though we did not observe any differences in L2-Cmu PK or exposure levels between male and female animals

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