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Beyond its antioxidant role, Vitamin C is a natural, mild antihistamine

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Internal wounds result from impaired immune and nervous system functions and/or decreased supply of blood, oxygen, or nutrients to that area, such as in cases of chronic medical illness (diabetes, atherosclerosis, and deep vein thrombosis)

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Meanwhile, long-term intracellular accumulation of platinum ions and persistent oxidative stress can activate the senescence program of renal tubular epithelial cells, induce cell cycle arrest and Senescence-Associated Secretory Phenotype (SASP), release a large number of pro-inflammatory and pro-fibrotic factors through paracrine effects, further amplify the local inflammatory response, and activate the proliferation and activation of renal interstitial fibroblasts (Nakao et al