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doi: 10.1158/1535-7163.MCT-14-0144 236 LylesRDZMartinezMJShermanBSchurerSBurnsteinKL

This suggests that the antidepressant effects of semaglutide, via GLP-1 receptor activation, may be closely linked to its neuroprotective and anti-inflammatory properties

Wegovy (semaglutide 2.4 mg) was FDA-approved for chronic weight management in June 2021 and received a supplemental approval for cardiovascular risk reduction in March 2024

To further examine the possibility that MK-801 could convey protraction, we synthesized a series of conjugates comprising MK-801 in combination with other peptide analogues, peptide YY (PYY), glucose insulinotropic peptide (GIP) as well as a GIP/GLP-1 co-agonist, for which half-life extension has been shown to enhance weight loss efficacy 23,24,25,26

Expert Rev Mol Diagn 2020;20:4534 14

Regulation of Nrf2 signaling pathway in heart failure: role of extracellular vesicles and non-coding RNAs