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We note that MR-Egger regression has lower statistical power compared to other methods (e.g., IVW) due to its reliance on the Instrument Strength Independent of Direct Effect (InSIDE) assumption and its sensitivity to weak instruments

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The loss of insulin sensitivity of hippocampal CA1 pyramidal neurons can subsequently cause long-term Ca 2+ -dependent afterhyperpolarizations (AHPs), which can produce significant cognitive and memory impairment in the short term and throughout life, contributing to depression (122, 123)

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Semaglutide and Sodium N -(8-[2-Hydroxybenzoyl] amino) caprylate (SNAC) Mean AUC 024h for semaglutide at steady state was 761.96 nmolh/L and C max was 37.35 nmol/L