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Li, C., Chen, Y
Yes, it is possible to lose some lean mass during any weight-loss phase, including while using a GLP-1
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Other authors have described that p38, a member of the family of MAP kinases, plays an important role during the early stages of myelination induced by both ascorbate and laminin (Fragoso et al., Antioxidant role of vitamin C in CNS The brain consumes 20% of the total body oxygen and has a high metabolic rate, making it a readily oxidizable tissue (Ereciska and Silver, 1997)
Many athletes I work with who follow intermittent fasting also partake in fasted cardio, but there are no meaningful benefits of fasted cardio over unfasted cardio, so do what works for your schedule