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The relationship between muscle mass and weight-loss response can be summarized as a metabolic chain: Muscle mass supports resting metabolic rate Resting metabolic rate influences how many calories the body burns each day Daily calorie burn affects how strongly appetite suppression translates into weight loss Resistance training and adequate protein intake can help support muscle maintenance during weight loss

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Nutritional Priorities to Support GLP-1 Therapy A pragmatic approach to nutrition and lifestyle counseling and support is recommended to maximize benefits, minimize potential risks, and increase efficiency of GLP-1 therapy for weight reduction

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SCFAs have the potential to stimulate host G-protein-coupled receptor (GPR) pathways that affect the secretion of renin and blood pressure (Pluznick et al., 2013)