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The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders

Novo Nordisk advises starting the oral semaglutide medication at 3 mg once daily for 30 days and then increasing it to 7 mg once daily

Future studies should prioritize defining the precise abundance threshold of Akkermansia muciniphila that balances its beneficial and deleterious effects on the intestinal barrier, investigating the molecular mediators (e.g., specific metabolites or surface proteins) that underpin its dual regulatory role, and developing targeted interventions (e.g., precision probiotics or microbiota modulators) to sustain its homeostatic levelswith the goal of ultimately mitigating OA progression via the gut-joint axis

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Participants who had been on the medication for 36 weeks (average weight loss of 20.9%) were then randomized to continue or switch to placebo

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