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These molecules are more resistant to degradation by DPP-4, which results in a prolonged half-life in comparison with endogenous GLP-1

Recent updates on GLP-1 agonists: Current advancements & challenges. Tirzepatide: Food & Drug Administration (2021)

Yes, but as part of its intended mechanism

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Genetic factors, adherence, diet, physical activity, and baseline metabolic health all influence treatment response