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C2 tended to show higher levels of monocytes, macrophage M0, and neutrophils, whereas C1 showed relatively higher distributions of CD8 T cells and macrophage M2 in several samples ( Figure 4F )

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Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner (Meurot et al., 2022)

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