Therefore, Ipamorelin attracts significant attention because it triggers clean growth hormone pathways without spiking baseline cortisol, prolactin, or aldosterone levels during active assays
doi: 10.1016/j.neulet.2009.02.016 33 FujitaK.SeikeT.YutsudoN.OhnoM.YamadaH.YamaguchiH.et al
GLP-1 receptor agonists (GLP-1s)better known by brand names Ozempic, Wegovy, Mounjaro, or Zepbound are often referred to as miracle drugs. GLP-1s were originally developed to help regulate blood sugar in people with type 2 diabetes
NAD+ levels decline with age : 40-year-old adults have ~50 % of the NAD+ levels of 20-year-olds 60-year-old adults have ~25 % of younger NAD+ levels The decline is visible in all tissues , muscle, liver, brain, skin, blood The mechanism of decline is multifactorial : Increased CD38 activity , the enzyme that breaks NAD+ down
GLP-1RAs and Renal Outcomes Accumulating clinical evidence demonstrates that GLP-1 RAs have beneficial effects on renal outcomes
And as I mentioned, some people are taking cispeptin antagonists