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We believe that it is not indicated unless significant pain, cosmetic, or pressure symptoms remain after a fair trial of thyroid therapy, and probably steroid therapy, but is appropriate in some cases

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What are the primary signs of taking too high a dose

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DOI: 10.1038/jid.2014.371 57

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Because individual responses vary, the clinicians experience and the patients symptom profile guide titration

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A C677T mutation is associated with elevated homocysteine levels

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J Pharmacol Exp Ther 1994

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