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and (3) Low: primarily animal models or small uncontrolled human studies

For instance, while quercetin has been reported to activate both enzymes, curcumin has shown potential as an activator of SIRT1, promoting its deacetylase activity and contributing to anti-inflammatory effects 178

Maedica J Clin Med

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Detoxification Benefits Reduce Glutathione also helps detoxify the body

It may also theoretically interact with medications metabolised by certain liver enzymes (particularly CYP3A4 and CYP2D6), such as ciclosporin and some statins, potentially affecting drug levels in the blood