Tretinoin (prescription retinoid): 4 of 10 (40%)
Inflammation reduction: It supports antioxidant enzymes that calm the inflammation that drives visible aging
A zebrafish study demonstrated that AGAT and GAMT were broadly expressed in multiple tissues (central nervous system, liver, and pancreas) in the same pattern as the homologous genes expressed in mammal tissues [30]
Glutathione plays a variety of roles in the body, including: regenerating other antioxidants (e.g., vitamin C, vitamin E) neutralizing free radicals detoxification of certain drugs regulating the immune system managing inflammation supporting various bodily systems (e.g., nervous system, pulmonary system) delaying cell aging Glutathione depletion is also linked to numerous health issues, including increased susceptibility to infectious diseases and illnesses, oxidative stress, and certain chronic diseases, such as type 2 diabetes, certain types of cancer, kidney disease, neurodegenerative disease, liver disease, and cardiovascular disease ( 1 , 2 )
however, the exact mechanism of topiramate treatment of migraine deserves further investigation, as there is less experimental evidence of topiramate prophylactic treatment of migraine
Its primary biological function is to protect cellular machinery from oxidative stress by neutralizing reactive oxygen species (ROS), such as superoxide radicals and hydrogen peroxide, which are natural but destructive byproducts of cellular energy production
