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has consulted for or received lecture fees from Amgen, AstraZeneca, Boehringer Ingelheim, Eli Lilly and Company, Hanmi Pharmaceuticals, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer and Sanofi and received grant support from AstraZeneca, Boehringer Ingelheim, Novartis and Roche Diagnostics through his institution, the University of Glasgow

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Plateaus typically last 2-8 weeks, though individual duration varies significantly

Rapid weight loss, hormonal changes, and improved insulin sensitivity may lead to missed periods, irregular cycles, spotting, or changes in menstrual flow

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Avoid alcohol during dose escalation or severe side effects