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It can pass easily to the brain and is both water and fat-soluble Liu and colleagues tested aged rats with oral acetyl-L-carnitine and lipoic acid to see if the supplementation reduced mitochondrial aging in the brain [1] A group from Oregon State University reviewed the literature and suggested that together, acetyl-L-carnitine and lipoic acid were able to protect the heart from aging as well as reverse age-related changes [2]

Finally, a basalforebrain AgRP circuit has been identified, whereby AgRP elicits increased food intake through projections directly to the BST (95)

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JH: Writing original draft, Methodology, Conceptualization, Writing review and editing

10.1016/j.tcb.2015.05.004 91

Triglycerides came down to 198