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Lifestyle changes such as quitting smoking, maintaining a moderate weight, reducing stress, and limiting alcohol consumption can help reduce the risk of ED

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Avoid Excessive Alcohol Consumption Excessive alcohol consumption can deplete glutathione levels and lead to oxidative stress

the frequencies and function of immune cells were analyzed by flow cytometry

Mitochondrial function, especially respiration and ATP production, has been demonstrated to decline with age and even be an important mediator of senescence (Wallace et al., 2010)

It has been shown in the literature (45, 46) that nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2-keap1) is the main mechanism of resistance to oxidative stress, and demethylation of keap1 promoter activates the expression of Keap1 protein, which promotes the degradation of Nrf2 proteasome and attenuates Nrf2 activity, leading to the reduction of resistance to oxidative stress and ultimately causing the cataract occurrence