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Combination therapy with these agents is commonly employed in clinical practice when glycemic targets are not achieved with initial therapy

In the phase 3 REDEFINE 1 trial, the combination of cagrilintide and semaglutide yielded a mean 20% reduction in body weight over 68 weeks in adults with overweight or obesity, significantly outperforming placebo and either agent alone

doi: 10.1016/j.cyto.2023.156144 185 Sharifi-RadJRayessYERizkAASadakaCZgheibRZamWet al

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But the model covers only a fraction of the population that could benefit

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