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RIBBON-1: Randomized, double-blind, placebo-controlled, phase III trial of chemotherapy with or without bevacizumab for first-line treatment of human epidermal growth factor receptor 2-negative, locally recurrent or metastatic breast cancer

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It gets its name from its circular rash, which is often red, swollen, and cracked, according to the Centers for Disease Control and Prevention(CDC)

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People may not be able to take vitamin B12 shots if they have a history of sensitivity to vitamin B12