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In particular, they found that the activation of GLP-1R promoted the secretion of atrial natriuretic peptide (ANP) and lowered blood pressure

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So when Stephen Bloom's paper came out in January of 1996, and he was the first one to call GLP-1 a neurotransmitter, I think, but I was already way into actually screening these kind of molecules that later then became liraglutide

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Notably, patients with a redeemed prescription of DPP-4i exhibited better adherence, suggesting that differences in outcomes were not attributed to variations in medication compliance

doi: 10.3390/jcm10050985 174 UnniSWittbrodtEMaJSchauerhamerMHurdJRuiz-NegrnNet al