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These effects are usually mild to moderate and often improve as patients adjust to the medication over several weeks

Preliminary clinical studies suggest CoQ10 (300400 mg/day) improves fatigue and sleep disturbances, but larger trials are needed for confirmation

Moreover, in hepatocellular carcinoma (HCC), antiangiogenic tyrosine kinase inhibitors (TKIs) are effective therapeutic agents and the main therapeutic effect is to induce severe hypoxia in the tumor microenvironment (TME) through depletion of the vascular density of tumor

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