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The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental methods and to assess their influence on the development of T2DM

Metabolic tracing studies further demonstrate that systemic NAD pools undergo inter-organ redistribution and are influenced by microbial metabolism and circulatory exchange [107, 108], indicating that NAD functions within a dynamic network rather than as a static intracellular reservoir [109]