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The approved BMI thresholds match the FDA standard: 30 or higher, or 27 or higher with at least one weight-related comorbidity

Fish Shellfish Immunol 49:427435 Stec DE, Gordon DM, Hipp JA, Hong S, Mitchell ZL, Franco NR et al (2019) Loss of hepatic PPAR promotes inflammation and serum hyperlipidemia in diet-induced obesity

Finally, prophylactic supplementation with L-carnitine seems reasonable in high risk patients