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Description

Nat Rev Genet

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Cells found in the lining of the small intestine (called L-cells) are the major source of glucagon-like peptide 1, although it is also secreted in smaller quantities by the pancreas and the central nervous system

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Patient demographics are shown in Table 1

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Phase 2 tested 1 mg, 4 mg, 8 mg, and 12 mg

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These negative effects often manifest early in the therapy during dosage escalation and are normally temporary, ameliorating with time

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PMID: 2832504

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