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Direct Effects of Exendin-(9,39) and GLP-1-(9,36)Amide on Insulin Action, B-Cell Function, and Glucose Metabolism in Nondiabetic Subjects

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Reported roughly 28% to 30% average weight loss at higher doses, the highest reported in a large Phase 3 obesity trial

Three years later, a significant amount of that plaque is gone

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The relationship between GLP-1 receptor agonists and thyroid function has been a subject of clinical interest, particularly regarding thyroid C-cells and potential effects on thyroid hormone levels