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Figure 2: Changes in body weight from baseline to the end of treatment at week 26 associated with the treatment policy estimand, in the randomly assigned treatment groups administered either 0.3 mg of cagrilintide, 0.6 mg of cagrilintide, 1.2 mg of cagrilintide, 2.5 mg of cagrilintide, 4.5 mg of cagrilintide, 3.0 mg of liraglutide, or a placebo

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Day 1: 100-200mg NAD IV (1-4 hrs) Day 4: 25mg NAD SQ Day 6: 25mg NAD SQ Daily: 250mg NR/NMN in the morning Week 2 We increase the SQ shots here to extend the life of the initial IV dose of NAD