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21 Given this critical findings, The ADA advises using GLP-1 RAs to treat type 2 diabetes in adults with MASH, citing histological benefits demonstrated in the mentioned phase 2 randomized controlled trials

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The metabolic effects of AKI within the kidney are well-described: disruption of mitochondrial structure, dynamics, biogenesis, and basic electron transport chain function are all present 36

Immunofluorescence staining showed that, compared with IL-1-treated ECs, ferrostatin-1-induced inhibition of ferroptosis restored ZO-1 and connexin 43 fluorescence intensity in IL-1-treated ECs (Fig

Across oncology, cardiometabolic disease, liver and rare disorders, several late-stage readouts stood out not because they met endpoints, but because they reset expectations introducing new standards of care, validating new platforms, or delivering benefits where progress had stalled for decades