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During 18 months of treatment, the proportion of men with testosterone levels in the normal range rose from 53% to 77%

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What's remarkable, however, is that berberine treatment restored GLP-1 secretion in the HFD-fed mice

The primary limitations identified included the absence of a list of excluded studies and justification, as well as a written or registered protocol for the included studies, a lack of detailed funding sources, an assessment of risk of bias, and a discussion regarding the heterogeneity observed