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Cell Reports (2018) 10.1016/j.celrep.2018.05.054 Follow-up study showing that p53 mutations (common in cancer cells) confer resistance to FOXO4-DRI, highlighting the p53-dependent mechanism and the importance of functional p53 for the senolytic effect

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It is abundant in the seeds and sprouts of broccoli and other cruciferous plants, and has shown promise in fighting damage caused by oxidative stress in animal models of brain and spinal cord injury